NP-06 · 14 pages · expanded round
Seven cohorts (37,874 genes), HPA local-expression and GWAS credible-set evidence layers,
and a five-pocket de novo program. KLK10 leads the v3 ranking; 4,065 molecule–pocket pairs
were screened and 75 leads finalised, 50 of them reaching the catalytic site and all 75
absent from ChEMBL by standard InChIKey. Includes the pose-validity audit that found and
fixed a physically impossible-geometry defect in the search.
Target discovery · Docking · De novo design · Pose audit
NP-05 · 9 pages
The two-compartment original: nasal and nasopharyngeal transcriptomes triangulated to
nominate two chemically unexploited epithelial serine proteases, with a structure-based
design protocol validated internally before it was let loose on the expanded pocket set.
Serine proteases · De novo inhibitors · Structure-based design
NP-04 · 14 pages
Registry gaps crossed with a replicating nasal transcriptomic signature: mechanisms already
tested in adjacent type-2 diseases but never registered in rhinitis. Includes a phase-3
outcome audit, an end-organ outcome audit, a PubMed cross-check and an inverse literature
sweep.
Registry gaps · Drug repurposing · Type-2 inflammation
NP-03 · 8 pages
Inverts the usual screen — drugs scored against rhinitis transcriptomes rather than the
reverse — and reports a null: no FDR-significant repositioning candidate. The value is the
ranked list of hypotheses that have never been tested in rhinitis, plus the null model that
makes the negative result interpretable.
Repurposing · Null result · Target inversion
NP-02 · 7 pages
An extension analysis with haemoglobin adjustment, two independent nasal cohorts and the
published clinical record — the follow-up that stress-tests the first-pass transfer-factor
finding instead of restating it.
Transfer factor · Extension · Confounder adjustment
NP-01 · 11 pages
A mixture cannot be run through a compound–target pipeline, so the evidence chain is
inverted: from published porcine-spleen peptidomics to the disease transcriptome. The
parent-protein layer is coordinately suppressed in diseased nasal epithelium, but no
drug–target evidence emerges — a directional hypothesis, not efficacy evidence.
Peptidomics · Mixture · Hypothesis generation
NP-MOM · 3 pages · 中文
End-to-end reproduction of the mometasone-furoate arm: counts, design, DESeq2 fit, the
Stouffer combination with √n weights, and every recomputed number next to its delivered
counterpart. A reproduction artifact rather than a result claim.
复现 · Reproduction · Meta-analysis
